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CAT guide: Search strategy

How to make a CAT (Critically Appraised Topic), a short summary of the best available evidence, created to answer a specific clinical question.

General aspects


P = adolescents with obsessive compulsive disorder

I =  cognitive behavior therapy combined with medication (SSRIs)

C = medication-only (SSRIs)

O = daily functioning, performance at school, complaints/symptoms

S = randomized controlled trial


("Obsessive-Compulsive Disorder"[Mesh] OR obsessive compulsive[tiab] OR ocd[tiab]) AND ("Cognitive Therapy"[Mesh] OR cognitive ther*[tiab]  OR cognitive behav*[tiab]) AND ("Serotonin Uptake Inhibitors"[Mesh] OR "Serotonin Uptake Inhibitors" [Pharmacological Action] OR Serotonin Uptake Inhibitor*[tiab] OR serotonin reuptake inhibitor*[tiab] OR ssri *[tiab] OR sri*[tiab]) AND ("Adolescent"[Mesh] OR adolescen*[tiab] OR youth[tiab] OR teens[tiab] OR teenager*[tiab])

Filter: Randomized Controlled Trial


Cochrane Library

The Cochrane Library contains different types of evidence to inform healthcare decision-making. 

The two most relevant ones:

-  Cochrane Database of Systematic Reviews

-  Cochrane Central Register of Controlled Trials


How to search Cochrane Library?


Embase is a large database with articles of biomedical and pharmaceutical journals (all Medline records are included). Embase records are indexed according to the Emtree.


comprises biomedical research articles. More

How do I search PubMed?

A brief explanation of how PubMed processes a subject search.

How to use MeSH in Pubmed?

(3 min. Video, February 2013)


Sjoukje van der Werf's picture
Sjoukje van der Werf
+31 (0)50 361 6197/ 6200
Subjects:- Medicine

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